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个人简介
陈雄峰，海南省医学科永盈会体育投注青年PI、博士生导师。从事肿瘤微环境与基质免疫调控研究，重点探索癌症相关成纤维细胞（CAFs）的谱系起源、免疫调节功能及其信号转导网络，致力于开发肿瘤治疗新策略。近五年，在 Cancer Cell、J Exp Clin Cancer Res等学术期刊发表SCI论文10余篇。
学习和工作经历
2026.05 – 至今 永盈会体育投注青年PI、博士生导师
2023.01 - 2025.01 美国德州大学西南医学中心 博士后
2019.09 - 2022.06 福建医科大学病理学与病理生理学专业 博士
2012.08 - 2026.04 福州大学附属省立医院 药物临床试验与基础研究
2009.09 - 2012.06 福州大学生物化学与分子生物学专业 硕士
2001.09 - 2005.07 厦门集美大学生物工程专业 学士
研究方向
整合单细胞与空间组学、谱系追踪、多重免疫荧光、流式细胞及转基因小鼠模型等技术体系，聚焦肿瘤微环境与基质免疫调控网络，探寻具有转化潜力的治疗新靶点。
代表性学术论著
1.Zhuan Zhou*, Alessandro La Ferlita, Manoj H. Palavalli, Xiongfeng Chen, Lauren Tyler, Aslam Ejaz, Joal Beane, Patricio M. Polanco, Huocong Huang#, Alex C. Kim#. TWIST1 mediated transcriptional activation of SPON2 drives colorectal cancer peritoneal metastasis through stromal cell signaling network. Oncogene. 2026 Apr 3: 1-14.
2.Jianlin Chen*, Jing Chen, Xiang Lv, Xiongfeng Chen, Liu Ming, Xinghua Huang, Fuli Wen, Haijun Tang, Qi Gao, Chengxiu Liu, Jiamiao Weng, Zhixin Huang, Yue Zheng, Fan Lin, Wenshu Chen, Xiuling Shang, Chundong Yu#, Yi Huang#. Cancer-derived fucosylated exosomal miR-6842-3p as a novel marker promotes ESCC angiogenesis and metastasis via the PTEN/AKT/mTOR/IRF1/CXCL10 axis. Oncogene. 2026 Jan;45(1):104-20.
3.Chen, Xiongfeng*, Zhuan Zhou, Luyu Xie, Kailiang Qiao, Yiyue Jia, Shunheng Liu, Zeynep Yazgan, Francesca Rossi, Yang Liu, Bo Zhang, Patricio M. Polanco, Herbert J. Zeh, 3rd, Alex C. Kim#, Huocong Huang#. Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches. Cancer Cell. 2025 Dec 8; 43(12), 2224-2240.
4.Chen J*, Zheng Y, Wang Z, Gao Q, Hao K, Chen X, Ke N, Lv X, Weng J, Zhong Y, Huang Z, Fu M, Zhao L, Lin F, Mi H, Tang H#, Yu C#, Huang Y#. Development a glycosylated extracellular vesicle-derived miRNA Signature for early detection of esophageal squamous cell carcinoma. BMC Med. 2025 Jan 23;23(1):39.
5.Chen X*, Huang H#. Tumor cell-intrinsic epigenetic SETpoint of cancer-associated fibroblasts. Cancer Cell. 2024 May 13;42(5):744-746.
6. Zhuang W*, Liu C*, Hong Y*, Zheng Y, Huang M, Tang H, Zhao L, Huang Z, Tu M, Yu L, Chen J, Zhang Y, Chen X, Lin F, Gao Q, Yu C#, Huang Y#. Tumor-suppressive miR-4732-3p is sorted into fucosylated exosome by hnRNPK to avoid the inhibition of lung cancer progression. J Exp Clin Cancer Res. 2024 Apr 23;43(1):123.
